Nolato specializes in polymer-based product design and manufacturing to virtually design a device to automatically inject medicines, such as insulin for diabetic patients. Within this presentation different aspects of the product design cycle are considered, including co-simulations of the device operation during the actual injection process, misuse in case of forceful bending or opening of the loading tray, and drop tests of the autoinjector. Based on Altair’s optimization technology, alternatives for the rib structure of the casing are investigated. To assure manufacturability, molding and assembly simulations are performed to identify and mitigate problems likely to occur throughout the process.